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Compound Detail

CHEMBL369346

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O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc([N+](=O)[O-])c1

Basic Information

ChEMBL ID CHEMBL369346
Phase Preclinical
Structure Type MOL
InChI Key DRPLNMFPBUMNGK-GMAHTHKFSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

480.5
MW (Da)
3.17
ALogP
7
HBA
5
HBD
146.0
PSA (Ų)
0.20
QED
0
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H28N4O6
MW 480.52
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -1.03

Activity Summary

EC50 2 meas. best 9.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL213
EC50 9.05 9.05 0.9 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 9.0 9.0 1.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15603933 10.1016/j.bmcl.2004.11.001 Beta-3 adrenergic receptor 1
15603933 10.1016/j.bmcl.2004.11.001 Beta-1 adrenergic receptor 1
15603933 10.1016/j.bmcl.2004.11.001 Adrenergic receptor beta; ADRB1 & ADRB3 1

Data from ChEMBL 36 via Core Engine