Assay Detail
Functional
CHEMBL834707
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration againstHuman cell lung carcinoma cell line NCI-H69/LX4; n=3
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | carcinoma cell line |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and in vitro evaluation of dipeptide-based antibody minor groove binder conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.88 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117142 | — | — | 1 | 8.54 |
| CHEMBL263256 | — | — | 1 | 7.68 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.75 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117142 | — | IC50 | = | 2.87 | nM | 8.54 |
| CHEMBL263256 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 2820.0 | nM | 5.55 |