Assay Detail
Functional
CHEMBL834711
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against TNF-alpha production in THP-1 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.11 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365359 | — | — | 1 | 8.28 |
| CHEMBL195188 | — | — | 1 | 8.26 |
| CHEMBL197041 | — | — | 1 | 7.81 |
| CHEMBL265032 | — | — | 1 | 7.67 |
| CHEMBL197267 | — | — | 1 | 7.40 |
| CHEMBL196295 | — | — | 1 | 7.40 |
| CHEMBL436291 | — | — | 1 | 7.30 |
| CHEMBL193563 | — | — | 1 | 7.20 |
| CHEMBL197096 | — | — | 1 | 7.17 |
| CHEMBL372301 | — | — | 1 | 7.04 |
| CHEMBL193992 | — | — | 1 | 7.03 |
| CHEMBL426466 | — | — | 1 | 6.96 |
| CHEMBL363600 | — | — | 1 | 6.26 |
| CHEMBL193494 | — | — | 1 | 6.18 |
| CHEMBL196847 | — | — | 1 | 5.91 |
| CHEMBL193983 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365359 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL195188 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL197041 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL265032 | — | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL197267 | — | IC50 | = | 40.2 | nM | 7.40 |
| CHEMBL196295 | — | IC50 | = | 40.2 | nM | 7.40 |
| CHEMBL436291 | — | IC50 | = | 50.1 | nM | 7.30 |
| CHEMBL193563 | — | IC50 | = | 63.6 | nM | 7.20 |
| CHEMBL197096 | — | IC50 | = | 67.6 | nM | 7.17 |
| CHEMBL372301 | — | IC50 | = | 92.2 | nM | 7.04 |
| CHEMBL193992 | — | IC50 | = | 93.4 | nM | 7.03 |
| CHEMBL426466 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL363600 | — | IC50 | = | 552.3 | nM | 6.26 |
| CHEMBL193494 | — | IC50 | = | 661.0 | nM | 6.18 |
| CHEMBL196847 | — | IC50 | = | 1245.0 | nM | 5.91 |
| CHEMBL193983 | — | IC50 | = | 1286.0 | nM | 5.89 |