Assay Detail
Functional
CHEMBL834872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration-Relaxation Studies was exerted on Guinea Pig Tracheal Rings Precontracted by Carbachol by the compound in presence of Adenosine antagonist DMPX ( E-4 M)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.38 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2096798 | — | — | 1 | 4.64 |
| CHEMBL368880 | — | — | 1 | 4.44 |
| CHEMBL186113 | GW-328267 | 1.0 | 1 | 4.34 |
| CHEMBL464859 | NECA | — | 1 | 4.11 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2096798 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL368880 | — | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL186113 | GW-328267 | EC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL464859 | NECA | EC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL477 | ADENOSINE | EC50 | = | 340000.0 | nM | - |