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Assay Detail

CHEMBL835781

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against peroxidation of rabbits red blood cell (RBC) membrane ghost induced by gamma-ray irradiation
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Confidence 1 — Organism
Curated By Intermediate

Target

Oryctolagus cuniculus (CHEMBL374)
Type ORGANISM
Organism Oryctolagus cuniculus

Publication

Quantitative structure-activity relationship studies for antioxidant hydroxybenzalacetones by quantum chemical- and 3-D-QSAR(CoMFA) analyses.
Yamagami C, Akamatsu M, Motohashi N, Hamada S, Tanahashi T.
Bioorg Med Chem Lett (2005) 15 : 2845 -2850
PubMed 15911266 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.12 5.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL371357 1 5.84
CHEMBL439677 1 5.71
CHEMBL381861 1 5.66
CHEMBL75390 1 5.63
CHEMBL320917 1 5.60
CHEMBL72918 1 5.49
CHEMBL306339 1 5.48
CHEMBL74945 1 5.44
CHEMBL196189 1 5.40
CHEMBL72834 1 5.20
CHEMBL196371 1 5.10
CHEMBL195938 1 5.10
CHEMBL106509 DEHYDROZINGERONE 1 4.94
CHEMBL380986 1 4.45
CHEMBL412355 1 4.42
CHEMBL196137 1 4.29
CHEMBL370174 1 4.22
CHEMBL9184 1 4.18

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL371357 IC50 = 1428.89 nM 5.84
CHEMBL439677 IC50 = 1958.84 nM 5.71
CHEMBL381861 IC50 = 2187.76 nM 5.66
CHEMBL75390 IC50 = 2338.84 nM 5.63
CHEMBL320917 IC50 = 2517.68 nM 5.60
CHEMBL72918 IC50 = 3250.87 nM 5.49
CHEMBL306339 IC50 = 3311.31 nM 5.48
CHEMBL74945 IC50 = 3630.78 nM 5.44
CHEMBL196189 IC50 = 3981.07 nM 5.40
CHEMBL72834 IC50 = 6324.12 nM 5.20
CHEMBL196371 IC50 = 7998.34 nM 5.10
CHEMBL195938 IC50 = 7998.34 nM 5.10
CHEMBL106509 DEHYDROZINGERONE IC50 = 11481.54 nM 4.94
CHEMBL380986 IC50 = 35481.34 nM 4.45
CHEMBL412355 IC50 = 37757.22 nM 4.42
CHEMBL196137 IC50 = 51168.18 nM 4.29
CHEMBL370174 IC50 = 60255.96 nM 4.22
CHEMBL9184 IC50 = 66069.34 nM 4.18