Assay Detail
Functional
CHEMBL836449
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In vitro inhibitory concentration against growth of U87MG glioblastoma cell line in clonogenic survival assay after 24 hr
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A non-crosslinking platinum-acridine hybrid agent shows enhanced cytotoxicity compared to clinical BCNU and cisplatin in glioblastoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.01 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 6.31 |
| CHEMBL611449 | Acridinylthiourea derivative and platinum conjugate | — | 1 | 6.12 |
| CHEMBL513 | CARMUSTINE | 4.0 | 1 | 5.85 |
| CHEMBL352708 | — | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11359 | CISPLATIN | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL611449 | Acridinylthiourea derivative and platinum conjugate | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL513 | CARMUSTINE | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL352708 | — | IC50 | = | 1830.0 | nM | 5.74 |