Assay Detail
Functional
CHEMBL836452
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Inhibitory activity on the proliferation of Human fibrosarcoma HT1080 cancer cells using MTT or sulforhodamine B assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Induction of apoptosis by a novel indirubin-5-nitro-3'-monoxime, a CDK inhibitor, in human lung cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.98 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | — | 1 | 5.32 |
| CHEMBL369303 | — | — | 1 | 5.23 |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | 4.38 |
| CHEMBL368689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL369303 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1276127 | INDIRUBIN | IC50 | = | 42200.0 | nM | 4.38 |
| CHEMBL368689 | — | IC50 | > | 100000.0 | nM | - |