Assay Detail

CHEMBL836740

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Functional

Agonistic activity tested in isolated rabbit saphenous vein

ChEMBL ↗

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Target

Oryctolagus cuniculus (CHEMBL374) ↗

Open DB target context

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Oryctolagus cuniculus (CHEMBL374) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Oryctolagus cuniculus

CHEMBL374

Anchored from Assay target.

Protein identity Oryctolagus cuniculus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Oryctolagus cuniculus
Tissue	Saphenous vein
Confidence	1 — Organism
Curated By	Intermediate

Target

Oryctolagus cuniculus (CHEMBL374) ↗

Type	ORGANISM
Organism	Oryctolagus cuniculus

Publication

2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.

Prisinzano T, Dukat M, Law H, Slassi A, MacLean N, DeLannoy I, Glennon RA.
Bioorg Med Chem Lett (2004) 14 : 4697 -4699
PubMed 15324890 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.11	6.11

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL361729	—	—	1	6.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL361729	—	EC50	=	780.0	nM	6.11