Assay Detail
Functional
CHEMBL838372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Enhancement of currents elicited by GABA at EC5 (6-12 uM)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-1/beta-2/gamma-2 (CHEMBL2095172) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.08 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23497 | — | — | 1 | 5.70 |
| CHEMBL681 | ETOMIDATE | 4.0 | 1 | 5.60 |
| CHEMBL22676 | — | — | 1 | 4.70 |
| CHEMBL279678 | S-ETOMIDATE | -1.0 | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23497 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL681 | ETOMIDATE | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL22676 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL279678 | S-ETOMIDATE | EC50 | = | 47000.0 | nM | 4.33 |