Assay Detail
Binding
CHEMBL838601
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Mean functional activity against human H3 receptor
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
4-phenoxypiperidines: potent, conformationally restricted, non-imidazole histamine H3 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 21 | 9.25 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194441 | — | — | 1 | 9.90 |
| CHEMBL129542 | JNJ-5207852 | — | 1 | 9.84 |
| CHEMBL427177 | — | — | 1 | 9.76 |
| CHEMBL193381 | — | — | 1 | 9.67 |
| CHEMBL372471 | — | — | 1 | 9.59 |
| CHEMBL194541 | — | — | 1 | 9.59 |
| CHEMBL195815 | — | — | 1 | 9.49 |
| CHEMBL193934 | — | — | 1 | 9.48 |
| CHEMBL439676 | — | — | 1 | 9.47 |
| CHEMBL370169 | — | — | 1 | 9.45 |
| CHEMBL195826 | — | — | 1 | 9.34 |
| CHEMBL191405 | — | — | 1 | 9.33 |
| CHEMBL194092 | — | — | 1 | 9.32 |
| CHEMBL194090 | — | — | 1 | 9.18 |
| CHEMBL372935 | — | — | 1 | 9.13 |
| CHEMBL195099 | — | — | 1 | 9.09 |
| CHEMBL193861 | — | — | 1 | 8.99 |
| CHEMBL191992 | — | — | 1 | 8.93 |
| CHEMBL195777 | — | — | 1 | 8.69 |
| CHEMBL194548 | — | — | 1 | 8.57 |
| CHEMBL260374 | THIOPERAMIDE | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194441 | — | Kd | = | 0.1259 | nM | 9.90 |
| CHEMBL129542 | JNJ-5207852 | Kd | = | 0.1445 | nM | 9.84 |
| CHEMBL427177 | — | Kd | = | 0.1738 | nM | 9.76 |
| CHEMBL193381 | — | Kd | = | 0.2138 | nM | 9.67 |
| CHEMBL372471 | — | Kd | = | 0.257 | nM | 9.59 |
| CHEMBL194541 | — | Kd | = | 0.257 | nM | 9.59 |
| CHEMBL195815 | — | Kd | = | 0.3236 | nM | 9.49 |
| CHEMBL193934 | — | Kd | = | 0.3311 | nM | 9.48 |
| CHEMBL439676 | — | Kd | = | 0.3388 | nM | 9.47 |
| CHEMBL370169 | — | Kd | = | 0.3548 | nM | 9.45 |
| CHEMBL195826 | — | Kd | = | 0.4571 | nM | 9.34 |
| CHEMBL191405 | — | Kd | = | 0.4677 | nM | 9.33 |
| CHEMBL194092 | — | Kd | = | 0.4786 | nM | 9.32 |
| CHEMBL194090 | — | Kd | = | 0.6607 | nM | 9.18 |
| CHEMBL372935 | — | Kd | = | 0.7413 | nM | 9.13 |
| CHEMBL195099 | — | Kd | = | 0.8128 | nM | 9.09 |
| CHEMBL193861 | — | Kd | = | 1.023 | nM | 8.99 |
| CHEMBL191992 | — | Kd | = | 1.175 | nM | 8.93 |
| CHEMBL195777 | — | Kd | = | 2.042 | nM | 8.69 |
| CHEMBL194548 | — | Kd | = | 2.692 | nM | 8.57 |
| CHEMBL260374 | THIOPERAMIDE | Kd | = | 43.65 | nM | 7.36 |