Compound Detail
CHEMBL195777
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Basic Information
| ChEMBL ID | CHEMBL195777 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LFGAXDHNYKZHFI-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
349.5
MW (Da)
4.56
ALogP
4
HBA
0
HBD
29.8
PSA (Ų)
0.61
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 8.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL264 | Kd | 8.69 | 8.69 | 2.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Kd | = | 2.042 | nM | 8.69 | Mean functional activity against human H3 receptor | 15771465 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15771465 | 10.1021/jm049212n | Histamine H3 receptor | 1 |
Data from ChEMBL 36 via Core Engine