Assay Detail
Binding
CHEMBL839501
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Binding affinity for delta opioid receptor of rat brain
13
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.18 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408680 | — | — | 1 | 9.96 |
| CHEMBL361033 | — | — | 2 | 9.52 |
| CHEMBL361274 | — | — | 1 | 9.05 |
| CHEMBL188558 | — | — | 1 | 8.28 |
| CHEMBL362514 | — | — | 2 | 7.82 |
| CHEMBL366311 | — | — | 1 | 7.67 |
| CHEMBL841 | LOPERAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL440380 | — | — | 2 | 7.20 |
| CHEMBL188565 | — | — | 1 | - |
| CHEMBL186527 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408680 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL361033 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL361274 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL188558 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL362514 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL361033 | — | Ki | = | 19.4 | nM | 7.71 |
| CHEMBL366311 | — | Ki | = | 21.5 | nM | 7.67 |
| CHEMBL362514 | — | Ki | = | 49.6 | nM | 7.30 |
| CHEMBL841 | LOPERAMIDE | Ki | = | 50.1 | nM | 7.30 |
| CHEMBL440380 | — | Ki | = | 62.7 | nM | 7.20 |
| CHEMBL188565 | — | Ki | > | 100.0 | nM | - |
| CHEMBL186527 | — | Ki | > | 100.0 | nM | - |
| CHEMBL440380 | — | Ki | > | 100.0 | nM | - |