Assay Detail
Binding
CHEMBL839554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-DAMGO binding to recombinant human Opioid receptor mu 1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.40 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366917 | — | — | 1 | 9.30 |
| CHEMBL362202 | DEPROTECTED COGENER OF M6G | — | 1 | 8.46 |
| CHEMBL359644 | — | — | 1 | 8.27 |
| CHEMBL359534 | — | — | 1 | 8.06 |
| CHEMBL1330 | MORPHINE GLUCURONIDE | 2.0 | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366917 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL362202 | DEPROTECTED COGENER OF M6G | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL359644 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL359534 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL1330 | MORPHINE GLUCURONIDE | Ki | = | 12.9 | nM | 7.89 |