Assay Detail
Binding
CHEMBL839604
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Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from rat hippocampus
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.03 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190032 | — | — | 1 | 7.79 |
| CHEMBL190586 | — | — | 1 | 7.77 |
| CHEMBL192119 | — | — | 1 | 7.65 |
| CHEMBL192941 | — | — | 1 | 7.62 |
| CHEMBL193999 | — | — | 1 | 7.46 |
| CHEMBL301707 | — | — | 1 | 7.30 |
| CHEMBL192659 | — | — | 1 | 7.08 |
| CHEMBL192603 | — | — | 1 | 6.89 |
| CHEMBL426817 | — | — | 1 | 6.71 |
| CHEMBL190226 | — | — | 1 | 6.42 |
| CHEMBL190034 | — | — | 1 | 6.28 |
| CHEMBL190384 | — | — | 1 | 6.25 |
| CHEMBL415774 | — | — | 1 | 6.19 |
| CHEMBL372073 | — | — | 1 | - |
| CHEMBL189437 | — | — | 1 | - |
| CHEMBL190301 | — | — | 1 | - |
| CHEMBL191425 | — | — | 1 | - |
| CHEMBL57163 | — | — | 1 | - |
| CHEMBL2113056 | — | — | 1 | - |
| CHEMBL365541 | — | — | 1 | - |
| CHEMBL372222 | — | — | 1 | - |
| CHEMBL190525 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190032 | — | Ki | = | 16.14 | nM | 7.79 |
| CHEMBL190586 | — | Ki | = | 16.9 | nM | 7.77 |
| CHEMBL192119 | — | Ki | = | 22.36 | nM | 7.65 |
| CHEMBL192941 | — | Ki | = | 24.01 | nM | 7.62 |
| CHEMBL193999 | — | Ki | = | 35.01 | nM | 7.46 |
| CHEMBL301707 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL192659 | — | Ki | = | 82.99 | nM | 7.08 |
| CHEMBL192603 | — | Ki | = | 129.8 | nM | 6.89 |
| CHEMBL426817 | — | Ki | = | 192.9 | nM | 6.71 |
| CHEMBL190226 | — | Ki | = | 376.2 | nM | 6.42 |
| CHEMBL190034 | — | Ki | = | 525.5 | nM | 6.28 |
| CHEMBL190384 | — | Ki | = | 558.5 | nM | 6.25 |
| CHEMBL415774 | — | Ki | = | 650.6 | nM | 6.19 |
| CHEMBL372073 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL189437 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL190301 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL191425 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL57163 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2113056 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL365541 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL372222 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL190525 | — | Ki | > | 10000.0 | nM | - |