Assay Detail
Binding
CHEMBL839705
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Displacement of [3H]Ile5,6]-deltorphin II from delta opioid receptor of rat brain membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Effect of a 6-cyano substituent in 14-oxygenated N-methylmorphinans on opioid receptor binding and antinociceptive potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.64 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606768 | — | — | 1 | 7.04 |
| CHEMBL607350 | — | — | 1 | 6.97 |
| CHEMBL606707 | — | — | 1 | 6.75 |
| CHEMBL607347 | — | — | 1 | 6.71 |
| CHEMBL607349 | — | — | 1 | 6.30 |
| CHEMBL607348 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606768 | — | Ki | = | 91.6 | nM | 7.04 |
| CHEMBL607350 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL606707 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL607347 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL607349 | — | Ki | = | 498.0 | nM | 6.30 |
| CHEMBL607348 | — | Ki | = | 881.0 | nM | 6.05 |