Assay Detail
Binding
CHEMBL840049
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Inhibition of [3H]diprenorphine binding to rat Opioid receptor delta 1 expressed in C6 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective kappa-opioid receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.50 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573214 | NORBINALTORPHIMINE | — | 1 | 8.24 |
| CHEMBL2113078 | — | — | 1 | 8.07 |
| CHEMBL606959 | — | — | 1 | 7.01 |
| CHEMBL2113073 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573214 | NORBINALTORPHIMINE | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL2113078 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL606959 | — | Ki | = | 98.2 | nM | 7.01 |
| CHEMBL2113073 | — | Ki | = | 207.0 | nM | 6.68 |