Assay Detail
Binding
CHEMBL840061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]naloxone binding to rat brain homogenate Opioid receptor delta
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.93 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | — | 1 | 9.14 |
| CHEMBL191777 | — | — | 1 | 7.98 |
| CHEMBL278789 | DERMORPHIN | — | 1 | 6.53 |
| CHEMBL2371868 | — | — | 1 | 6.52 |
| CHEMBL317264 | — | — | 1 | 5.74 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 5.64 |
| CHEMBL2371865 | — | — | 1 | - |
| CHEMBL2371866 | — | — | 1 | - |
| CHEMBL370392 | — | — | 1 | - |
| CHEMBL2371867 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL191777 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL278789 | DERMORPHIN | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL2371868 | — | Ki | = | 304.0 | nM | 6.52 |
| CHEMBL317264 | — | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL2371865 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2371866 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL370392 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2371867 | — | Ki | > | 10000.0 | nM | - |