Assay Detail
Binding
CHEMBL840089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]cAMP binding to recombinant human Phosphodiesterase 4AL (PDE4AL) in baculovirus expression system
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.41 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362175 | — | — | 1 | 6.99 |
| CHEMBL368696 | — | — | 1 | 6.95 |
| CHEMBL180015 | — | — | 1 | 6.90 |
| CHEMBL360527 | — | — | 1 | 6.86 |
| CHEMBL367846 | — | — | 1 | 6.83 |
| CHEMBL178801 | — | — | 1 | 6.81 |
| CHEMBL433774 | — | — | 1 | 6.78 |
| CHEMBL360481 | — | — | 1 | 6.76 |
| CHEMBL433761 | — | — | 1 | 6.76 |
| CHEMBL1203921 | — | — | 1 | 6.75 |
| CHEMBL360770 | — | — | 1 | 6.69 |
| CHEMBL361201 | — | — | 1 | 6.68 |
| CHEMBL178712 | — | — | 1 | 6.65 |
| CHEMBL179321 | — | — | 1 | 6.65 |
| CHEMBL433757 | — | — | 1 | 6.63 |
| CHEMBL369134 | — | — | 1 | 6.61 |
| CHEMBL178460 | — | — | 1 | 6.57 |
| CHEMBL368739 | — | — | 1 | 6.51 |
| CHEMBL178099 | — | — | 1 | 6.39 |
| CHEMBL360932 | — | — | 1 | 6.38 |
| CHEMBL361104 | — | — | 1 | 5.47 |
| CHEMBL362652 | — | — | 1 | 5.41 |
| CHEMBL444808 | — | — | 1 | 5.28 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.10 |
| CHEMBL179868 | — | — | 1 | 4.82 |
| CHEMBL440593 | CI-930 | — | 1 | - |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | - |
| CHEMBL434332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362175 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL368696 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL180015 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL360527 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL367846 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL178801 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL433774 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL360481 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL433761 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL1203921 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL360770 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL361201 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL178712 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL179321 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL433757 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL369134 | — | Ki | = | 244.0 | nM | 6.61 |
| CHEMBL178460 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL368739 | — | Ki | = | 309.0 | nM | 6.51 |
| CHEMBL178099 | — | Ki | = | 405.0 | nM | 6.39 |
| CHEMBL360932 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL361104 | — | Ki | = | 3390.0 | nM | 5.47 |
| CHEMBL362652 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL444808 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL63 | ROLIPRAM | Ki | = | 7940.0 | nM | 5.10 |
| CHEMBL179868 | — | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL440593 | CI-930 | Ki | > | 50000.0 | nM | - |
| CHEMBL28079 | ZAPRINAST | Ki | > | 50000.0 | nM | - |
| CHEMBL434332 | — | Ki | > | 50000.0 | nM | - |