Assay Detail
Binding
CHEMBL840206
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Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.86 | 9.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189414 | — | — | 1 | 9.79 |
| CHEMBL189395 | — | — | 1 | 9.61 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.55 |
| CHEMBL189449 | — | — | 1 | 9.18 |
| CHEMBL427516 | — | — | 1 | 9.05 |
| CHEMBL363321 | — | — | 1 | 7.52 |
| CHEMBL364806 | — | — | 1 | 7.42 |
| CHEMBL187160 | — | — | 1 | 7.40 |
| CHEMBL365249 | — | — | 1 | 7.07 |
| CHEMBL364835 | — | — | 1 | 7.05 |
| CHEMBL362133 | — | — | 1 | 6.90 |
| CHEMBL360600 | — | — | 1 | 6.70 |
| CHEMBL364845 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189414 | — | Ki | = | 0.1622 | nM | 9.79 |
| CHEMBL189395 | — | Ki | = | 0.2455 | nM | 9.61 |
| CHEMBL45 | MELATONIN | Ki | = | 0.2818 | nM | 9.55 |
| CHEMBL189449 | — | Ki | = | 0.6607 | nM | 9.18 |
| CHEMBL427516 | — | Ki | = | 0.8913 | nM | 9.05 |
| CHEMBL363321 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL364806 | — | Ki | = | 38.02 | nM | 7.42 |
| CHEMBL187160 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL365249 | — | Ki | = | 85.11 | nM | 7.07 |
| CHEMBL364835 | — | Ki | = | 89.13 | nM | 7.05 |
| CHEMBL362133 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL360600 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL364845 | — | Ki | = | 10964.78 | nM | 4.96 |