Assay Detail
Binding
CHEMBL840209
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Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.33 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.54 |
| CHEMBL189395 | — | — | 1 | 8.89 |
| CHEMBL189414 | — | — | 1 | 8.87 |
| CHEMBL427516 | — | — | 1 | 8.52 |
| CHEMBL189449 | — | — | 1 | 8.21 |
| CHEMBL364806 | — | — | 1 | 7.24 |
| CHEMBL362133 | — | — | 1 | 6.95 |
| CHEMBL187160 | — | — | 1 | 6.79 |
| CHEMBL363321 | — | — | 1 | 6.62 |
| CHEMBL364835 | — | — | 1 | 6.41 |
| CHEMBL365249 | — | — | 1 | 6.26 |
| CHEMBL360600 | — | — | 1 | 6.26 |
| CHEMBL364845 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 0.2884 | nM | 9.54 |
| CHEMBL189395 | — | Ki | = | 1.288 | nM | 8.89 |
| CHEMBL189414 | — | Ki | = | 1.349 | nM | 8.87 |
| CHEMBL427516 | — | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL189449 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL364806 | — | Ki | = | 57.54 | nM | 7.24 |
| CHEMBL362133 | — | Ki | = | 112.2 | nM | 6.95 |
| CHEMBL187160 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL363321 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL364835 | — | Ki | = | 389.05 | nM | 6.41 |
| CHEMBL365249 | — | Ki | = | 549.54 | nM | 6.26 |
| CHEMBL360600 | — | Ki | = | 549.54 | nM | 6.26 |
| CHEMBL364845 | — | Ki | = | 20417.38 | nM | 4.69 |