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Assay Detail

CHEMBL840216

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against Opioid receptor delta 1 from rat brain membranes using [3H]DADLE
ChEMBL ↗
100
Total Activities
100
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL269) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

3D-QSAR comparative molecular field analysis on opioid receptor antagonists: pooling data from different studies.
Peng Y, Keenan SM, Zhang Q, Kholodovych V, Welsh WJ.
J Med Chem (2005) 48 : 1620 -1629
PubMed 15743203 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 100 7.57 9.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL567175 NALTRINDOLE — 1 9.66
CHEMBL606795 — — 1 9.15
CHEMBL611398 — — 1 9.15
CHEMBL195784 — — 1 9.11
CHEMBL610798 — — 1 9.10
CHEMBL192443 — — 1 9.06
CHEMBL363777 — — 1 8.96
CHEMBL370544 — — 1 8.75
CHEMBL606740 — — 1 8.70
CHEMBL611131 — — 1 8.68
CHEMBL195684 — — 1 8.66
CHEMBL611393 — — 1 8.64
CHEMBL607118 — — 1 8.64
CHEMBL606741 — — 1 8.62
CHEMBL364247 — — 1 8.59
CHEMBL427546 — — 1 8.54
CHEMBL610620 — — 1 8.51
CHEMBL195770 — — 1 8.46
CHEMBL195879 — — 1 8.43
CHEMBL610880 — — 1 8.43
CHEMBL606607 — — 1 8.42
CHEMBL606676 — — 1 8.42
CHEMBL194033 — — 1 8.41
CHEMBL193586 — — 1 8.40
CHEMBL611132 — — 1 8.36
CHEMBL265033 — — 1 8.36
CHEMBL606675 — — 1 8.33
CHEMBL195756 — — 1 8.31
CHEMBL606739 — — 1 8.30
CHEMBL370966 — — 1 8.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL567175 NALTRINDOLE Ki = 0.2188 nM 9.66
CHEMBL606795 — Ki = 0.7079 nM 9.15
CHEMBL611398 — Ki = 0.7079 nM 9.15
CHEMBL195784 — Ki = 0.7762 nM 9.11
CHEMBL610798 — Ki = 0.7943 nM 9.10
CHEMBL192443 — Ki = 0.871 nM 9.06
CHEMBL363777 — Ki = 1.096 nM 8.96
CHEMBL370544 — Ki = 1.778 nM 8.75
CHEMBL606740 — Ki = 1.995 nM 8.70
CHEMBL611131 — Ki = 2.089 nM 8.68
CHEMBL195684 — Ki = 2.188 nM 8.66
CHEMBL611393 — Ki = 2.291 nM 8.64
CHEMBL607118 — Ki = 2.291 nM 8.64
CHEMBL606741 — Ki = 2.399 nM 8.62
CHEMBL364247 — Ki = 2.57 nM 8.59
CHEMBL427546 — Ki = 2.884 nM 8.54
CHEMBL610620 — Ki = 3.09 nM 8.51
CHEMBL195770 — Ki = 3.467 nM 8.46
CHEMBL195879 — Ki = 3.715 nM 8.43
CHEMBL610880 — Ki = 3.715 nM 8.43
CHEMBL606607 — Ki = 3.802 nM 8.42
CHEMBL606676 — Ki = 3.802 nM 8.42
CHEMBL194033 — Ki = 3.89 nM 8.41
CHEMBL193586 — Ki = 3.981 nM 8.40
CHEMBL265033 — Ki = 4.365 nM 8.36
CHEMBL611132 — Ki = 4.365 nM 8.36
CHEMBL606675 — Ki = 4.677 nM 8.33
CHEMBL195756 — Ki = 4.898 nM 8.31
CHEMBL606739 — Ki = 5.012 nM 8.30
CHEMBL370966 — Ki = 5.012 nM 8.30
CHEMBL425728 — Ki = 5.012 nM 8.30
CHEMBL608246 — Ki = 5.754 nM 8.24
CHEMBL611396 — Ki = 6.457 nM 8.19
CHEMBL610616 — Ki = 6.761 nM 8.17
CHEMBL178829 — Ki = 7.079 nM 8.15
CHEMBL606798 — Ki = 7.413 nM 8.13
CHEMBL364937 — Ki = 8.128 nM 8.09
CHEMBL329719 — Ki = 8.128 nM 8.09
CHEMBL606673 — Ki = 8.318 nM 8.08
CHEMBL607067 — Ki = 8.913 nM 8.05
CHEMBL195082 — Ki = 10.72 nM 7.97
CHEMBL611397 — Ki = 14.79 nM 7.83
CHEMBL195477 — Ki = 14.79 nM 7.83
CHEMBL607484 — Ki = 15.85 nM 7.80
CHEMBL610878 — Ki = 15.85 nM 7.80
CHEMBL317536 — Ki = 15.85 nM 7.80
CHEMBL363348 — Ki = 15.85 nM 7.80
CHEMBL370735 — Ki = 16.98 nM 7.77
CHEMBL611399 — Ki = 17.78 nM 7.75
CHEMBL611133 — Ki = 18.2 nM 7.74