Assay Detail
Functional
CHEMBL840553
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Compound was evaluated for inhibition of ex vivo ADP mediated platelet aggregation of human gel filtered platelets
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonpeptide glycoprotein IIB/IIIA inhibitors. 12. Potent and orally active centrally constrained thieno[2,3-c]pyridones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.10 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94367 | — | — | 1 | 8.15 |
| CHEMBL420989 | — | — | 1 | 8.10 |
| CHEMBL96189 | — | — | 1 | 7.89 |
| CHEMBL32960 | — | — | 1 | 7.60 |
| CHEMBL328478 | — | — | 1 | 7.60 |
| CHEMBL93364 | — | — | 1 | 6.82 |
| CHEMBL94457 | — | — | 1 | 6.66 |
| CHEMBL96923 | — | — | 1 | 6.58 |
| CHEMBL96784 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94367 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL420989 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL96189 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL32960 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL328478 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL93364 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL94457 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL96923 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL96784 | — | IC50 | = | 33000.0 | nM | 4.48 |