Assay Detail
Functional
CHEMBL840668
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Inhibitory activity against mutant murine leukemia cell line P388/AMSA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potential antitumor agents. 64. Synthesis and antitumor evaluation of dibenzo[1,4]dioxin-1-carboxamides: a new class of weakly binding DNA-intercalating agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.87 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90047 | — | — | 1 | 6.35 |
| CHEMBL89850 | — | — | 1 | 6.28 |
| CHEMBL88852 | — | — | 1 | 6.14 |
| CHEMBL88776 | — | — | 1 | 5.75 |
| CHEMBL89783 | — | — | 1 | 5.58 |
| CHEMBL89593 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90047 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL89850 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL88852 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL88776 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL89783 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL89593 | — | IC50 | = | 7700.0 | nM | 5.11 |