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Assay Detail

CHEMBL841435

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of ADP-induced platelet in rabbit platelet rich plasma
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Tissue Plasma
Confidence 1 — Organism
Curated By Expert

Target

Oryctolagus cuniculus (CHEMBL374)
Type ORGANISM
Organism Oryctolagus cuniculus

Publication

1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.
Meanwell NA, Roth HR, Smith EC, Wedding DL, Wright JJ, Fleming JS, Gillespie E.
J Med Chem (1991) 34 : 2906 -2916
PubMed 1654430 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 5.98 6.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL98738 1 6.12
CHEMBL99474 1 5.83

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL98738 EC50 = 750.0 nM 6.12
CHEMBL99474 EC50 = 1480.0 nM 5.83