Assay Detail
Functional
CHEMBL841578
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Concentration required to inhibit PAF (5*10e-8 M) induced platelet aggregation in rabbit platelet rich plasma(PRP) by 50%
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Analogues of platelet activating factor. 7. Bis-aryl amide and bis-aryl urea receptor antagonists of PAF.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.81 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145526 | — | — | 1 | 6.89 |
| CHEMBL144994 | — | — | 1 | 6.58 |
| CHEMBL145594 | — | — | 1 | 6.58 |
| CHEMBL358819 | — | — | 1 | 6.51 |
| CHEMBL357617 | — | — | 1 | 6.50 |
| CHEMBL145115 | — | — | 1 | 6.50 |
| CHEMBL280164 | APAFANT | 2.0 | 1 | 6.47 |
| CHEMBL344522 | — | — | 1 | 6.43 |
| CHEMBL143155 | — | — | 1 | 6.40 |
| CHEMBL145803 | — | — | 1 | 6.28 |
| CHEMBL296973 | — | — | 1 | 6.27 |
| CHEMBL141928 | — | — | 1 | 6.26 |
| CHEMBL143013 | — | — | 1 | 6.24 |
| CHEMBL146057 | — | — | 1 | 6.22 |
| CHEMBL344292 | — | — | 1 | 6.15 |
| CHEMBL357011 | — | — | 1 | 6.13 |
| CHEMBL342763 | — | — | 1 | 6.02 |
| CHEMBL357153 | — | — | 1 | 6.02 |
| CHEMBL356092 | — | — | 1 | 6.00 |
| CHEMBL357401 | — | — | 1 | 5.85 |
| CHEMBL142572 | — | — | 1 | 5.82 |
| CHEMBL145595 | — | — | 1 | 5.82 |
| CHEMBL297624 | — | — | 1 | 5.80 |
| CHEMBL143104 | — | — | 1 | 5.68 |
| CHEMBL144985 | — | — | 1 | 5.64 |
| CHEMBL145707 | — | — | 1 | 5.60 |
| CHEMBL142369 | — | — | 1 | 5.57 |
| CHEMBL344914 | — | — | 1 | 5.54 |
| CHEMBL144968 | — | — | 1 | 5.54 |
| CHEMBL144903 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145526 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL144994 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL145594 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL358819 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL357617 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL145115 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL280164 | APAFANT | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL344522 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL143155 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL145803 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL296973 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL141928 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL143013 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL146057 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL344292 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL357011 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL342763 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL357153 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL356092 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL357401 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL142572 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL145595 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL297624 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL143104 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL144985 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL145707 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL142369 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL344914 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL144968 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL144903 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL141330 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL343839 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL296958 | KADSURENONE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL145053 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL358310 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL345015 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL146002 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL145632 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL424308 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL356985 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL145470 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL646 | TRIAZOLAM | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL145743 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL661 | ALPRAZOLAM | IC50 | = | 41200.0 | nM | 4.38 |