Assay Detail
Functional
CHEMBL842320
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50 percent inhibitory concentration of compound to inhibit nitric oxide production induced by IFN-gamma in mouse macrophages
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.49 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389621 | HYDROCORTISONE | 4.0 | 1 | 8.00 |
| CHEMBL55760 | — | — | 1 | 7.16 |
| CHEMBL55309 | — | — | 1 | 6.22 |
| CHEMBL56503 | — | — | 1 | 6.16 |
| CHEMBL293517 | — | — | 1 | 6.10 |
| CHEMBL55218 | — | — | 1 | 6.05 |
| CHEMBL300760 | — | — | 1 | 5.66 |
| CHEMBL54167 | — | — | 1 | 5.29 |
| CHEMBL43043 | — | — | 1 | 5.25 |
| CHEMBL291547 | — | — | 1 | 5.21 |
| CHEMBL301402 | — | — | 1 | 5.14 |
| CHEMBL55042 | — | — | 1 | 4.89 |
| CHEMBL42755 | — | — | 1 | 4.89 |
| CHEMBL292387 | — | — | 1 | 4.85 |
| CHEMBL42239 | — | — | 1 | 4.57 |
| CHEMBL44192 | — | — | 1 | 4.52 |
| CHEMBL56114 | — | — | 1 | 4.51 |
| CHEMBL470029 | OLEANONIC ACID | — | 1 | 4.43 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
| CHEMBL55735 | — | — | 1 | - |
| CHEMBL300805 | — | — | 1 | - |
| CHEMBL55538 | — | — | 1 | - |
| CHEMBL55176 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389621 | HYDROCORTISONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL55760 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL55309 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL56503 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL293517 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL55218 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL300760 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL54167 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL43043 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL291547 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL301402 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL55042 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL42755 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL292387 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL42239 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL44192 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL56114 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL470029 | OLEANONIC ACID | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | > | 40000.0 | nM | - |
| CHEMBL55735 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL300805 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL55538 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL55176 | — | IC50 | > | 40000.0 | nM | - |