Assay Detail
Functional
CHEMBL842374
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Inhibition of Angiotensin II induced contraction of isolated rabbit aortic rings
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.77 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301705 | — | — | 1 | 6.96 |
| CHEMBL48824 | — | — | 1 | 6.66 |
| CHEMBL297653 | — | — | 1 | 6.28 |
| CHEMBL48195 | — | — | 1 | 6.26 |
| CHEMBL297202 | — | — | 1 | 5.20 |
| CHEMBL48168 | — | — | 1 | 5.19 |
| CHEMBL295737 | — | — | 1 | 4.85 |
| CHEMBL45814 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301705 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL48824 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL297653 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL48195 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL297202 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL48168 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL295737 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL45814 | — | IC50 | = | 17000.0 | nM | 4.77 |