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Assay Detail

CHEMBL842733

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required to inhibit 50% of cell growth on murine P388 D1 cells.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type P388
Confidence 1 — Organism
Curated By Expert

Target

P388 (CHEMBL389)
Type CELL-LINE
Organism Mus musculus

Publication

Sequential cytotoxicity: a theory evaluated using novel 2-[4-(3-aryl-2-propenoyloxy)phenylmethylene]cyclohexanones and related compounds.
Dimmock JR, Kandepu NM, Nazarali AJ, Motaganahalli NL, Kowalchuk TP, Pugazhenthi U, Prisciak JS, Quail JW, Allen TM, LeClerc R, Santos CL, De Clercq E, Balzarini J.
J Med Chem (2000) 43 : 3933 -3940
PubMed 11052798 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.65 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1203292 1 6.75
CHEMBL852 MELPHALAN 4.0 1 6.66
CHEMBL1203286 1 6.48
CHEMBL1735318 1 6.37
CHEMBL185 FLUOROURACIL 4.0 1 6.31
CHEMBL1203288 1 5.89
CHEMBL1969738 1 5.79
CHEMBL1203287 1 5.62
CHEMBL1203276 1 5.40
CHEMBL1203289 1 5.39
CHEMBL1901889 1 5.38
CHEMBL1203290 1 5.34
CHEMBL129166 1 5.04
CHEMBL128603 1 4.69
CHEMBL125360 1 4.66
CHEMBL129386 1 4.59
CHEMBL131988 1 -
CHEMBL129071 1 -
CHEMBL125802 1 -
CHEMBL129342 1 -
CHEMBL338528 1 -
CHEMBL129461 1 -
CHEMBL131369 1 -
CHEMBL338834 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1203292 IC50 = 180.0 nM 6.75
CHEMBL852 MELPHALAN IC50 = 220.0 nM 6.66
CHEMBL1203286 IC50 = 332.0 nM 6.48
CHEMBL1735318 IC50 = 425.0 nM 6.37
CHEMBL185 FLUOROURACIL IC50 = 490.0 nM 6.31
CHEMBL1203288 IC50 = 1290.0 nM 5.89
CHEMBL1969738 IC50 = 1610.0 nM 5.79
CHEMBL1203287 IC50 = 2410.0 nM 5.62
CHEMBL1203276 IC50 = 4020.0 nM 5.40
CHEMBL1203289 IC50 = 4030.0 nM 5.39
CHEMBL1901889 IC50 = 4180.0 nM 5.38
CHEMBL1203290 IC50 = 4550.0 nM 5.34
CHEMBL129166 IC50 = 9030.0 nM 5.04
CHEMBL128603 IC50 = 20300.0 nM 4.69
CHEMBL125360 IC50 = 21900.0 nM 4.66
CHEMBL129386 IC50 = 25500.0 nM 4.59
CHEMBL131988 IC50 > 50000.0 nM -
CHEMBL129071 IC50 > 50000.0 nM -
CHEMBL125802 IC50 > 50000.0 nM -
CHEMBL129342 IC50 > 50000.0 nM -
CHEMBL338528 IC50 > 50000.0 nM -
CHEMBL129461 IC50 > 50000.0 nM -
CHEMBL131369 IC50 > 50000.0 nM -
CHEMBL338834 IC50 > 50000.0 nM -