Assay Detail
Functional
CHEMBL843088
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Inhibition of nitric oxide (NO) production induced by interferon-gamma (IFN-gamma) in mouse macrophages
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 6.31 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 10.00 |
| CHEMBL1762621 | BARDOXOLONE METHYL | 3.0 | 1 | 10.00 |
| CHEMBL1093059 | BARDOXOLONE | 2.0 | 1 | 9.70 |
| CHEMBL8252 | — | — | 1 | 9.10 |
| CHEMBL389621 | HYDROCORTISONE | 4.0 | 1 | 8.00 |
| CHEMBL115128 | — | — | 1 | 7.70 |
| CHEMBL325626 | — | — | 1 | 7.40 |
| CHEMBL116803 | — | — | 1 | 7.16 |
| CHEMBL55760 | — | — | 1 | 7.16 |
| CHEMBL135519 | — | — | 1 | 7.00 |
| CHEMBL336184 | — | — | 1 | 7.00 |
| CHEMBL114353 | — | — | 1 | 7.00 |
| CHEMBL135767 | — | — | 1 | 7.00 |
| CHEMBL334260 | — | — | 1 | 6.70 |
| CHEMBL1765578 | — | — | 1 | 6.70 |
| CHEMBL55309 | — | — | 1 | 6.22 |
| CHEMBL56503 | — | — | 1 | 6.16 |
| CHEMBL134897 | — | — | 1 | 6.16 |
| CHEMBL293517 | — | — | 1 | 6.10 |
| CHEMBL135270 | — | — | 1 | 6.10 |
| CHEMBL55218 | — | — | 1 | 6.05 |
| CHEMBL42704 | — | — | 1 | 5.96 |
| CHEMBL300760 | — | — | 1 | 5.66 |
| CHEMBL433460 | — | — | 1 | 5.58 |
| CHEMBL135979 | — | — | 1 | 5.55 |
| CHEMBL337907 | — | — | 1 | 5.52 |
| CHEMBL296070 | — | — | 1 | 5.48 |
| CHEMBL135751 | — | — | 1 | 5.42 |
| CHEMBL54167 | — | — | 1 | 5.29 |
| CHEMBL44527 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1762621 | BARDOXOLONE METHYL | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1093059 | BARDOXOLONE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL8252 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL389621 | HYDROCORTISONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL115128 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL325626 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL116803 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL55760 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL135767 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL114353 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL336184 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL135519 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL334260 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1765578 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL55309 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL56503 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL134897 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL293517 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL135270 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL55218 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL42704 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL300760 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL433460 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL135979 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL337907 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL296070 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL135751 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL54167 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL44527 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL416274 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL43043 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL291547 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL46459 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL132550 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL290070 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL42755 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL337421 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL292387 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL446352 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL42286 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | > | 40000.0 | nM | - |
| CHEMBL135914 | — | IC50 | > | 40000.0 | nM | - |