Assay Detail
Functional
CHEMBL843090
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Inhibitory activity against nitric oxide production induced by interferon-gamma (IFN-gamma) in mouse macrophages
14
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of tricyclic compounds with enone functionalities in rings A and C: a novel class of highly active inhibitors of nitric oxide production in mouse macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.30 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093059 | BARDOXOLONE | 2.0 | 1 | 9.30 |
| CHEMBL356121 | — | — | 1 | 8.68 |
| CHEMBL389621 | HYDROCORTISONE | 4.0 | 1 | 8.00 |
| CHEMBL342544 | — | — | 1 | 7.28 |
| CHEMBL415458 | — | — | 3 | 7.24 |
| CHEMBL142344 | — | — | 1 | 7.21 |
| CHEMBL146553 | — | — | 1 | 7.12 |
| CHEMBL343629 | — | — | 1 | 7.04 |
| CHEMBL145011 | — | — | 1 | 6.51 |
| CHEMBL144916 | — | — | 1 | 6.32 |
| CHEMBL343446 | — | — | 1 | 5.80 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093059 | BARDOXOLONE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL356121 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL389621 | HYDROCORTISONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL342544 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL415458 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL142344 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL415458 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL415458 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL146553 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL343629 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL145011 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL144916 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL343446 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | > | 40000.0 | nM | - |