Assay Detail
Functional
CHEMBL843482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit electrically induced twitch by 50% in guinea pig ileum(GPI).
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.71 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | — | 1 | 6.38 |
| CHEMBL263670 | — | — | 1 | 5.96 |
| CHEMBL342209 | — | — | 1 | 5.75 |
| CHEMBL296603 | DELTORPHINE II | — | 1 | 5.28 |
| CHEMBL139885 | — | — | 1 | 5.16 |
| CHEMBL140384 | — | — | 1 | - |
| CHEMBL142547 | — | — | 1 | - |
| CHEMBL143354 | — | — | 1 | - |
| CHEMBL143208 | — | — | 1 | - |
| CHEMBL140845 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL263670 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL342209 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL296603 | DELTORPHINE II | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL139885 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL140384 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL142547 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL143354 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL143208 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL140845 | — | IC50 | > | 10000.0 | nM | - |