Assay Detail
Functional
CHEMBL843648
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Compound was evaluated for antagonistic activity against carbachol induced contractions in isolated guinea pig urinary bladder strips
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogues of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.46 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38756 | — | — | 1 | 4.85 |
| CHEMBL287834 | — | — | 1 | 4.48 |
| CHEMBL291280 | — | — | 1 | 4.40 |
| CHEMBL39922 | — | — | 1 | 4.35 |
| CHEMBL39843 | — | — | 1 | 4.24 |
| CHEMBL289894 | — | — | 1 | - |
| CHEMBL290715 | — | — | 1 | - |
| CHEMBL38423 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38756 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL287834 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL291280 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL39922 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL39843 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL289894 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL290715 | — | Ki | = | 115000.0 | nM | - |
| CHEMBL38423 | — | Ki | > | 50000.0 | nM | - |