Assay Detail

CHEMBL843655

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Functional

Tested for antagonist activity in guinea pig ileum by (GPI) assay.

ChEMBL ↗

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Target

Cavia porcellus (CHEMBL369) ↗

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Primary target Cavia porcellus

CHEMBL369

Anchored from Assay target.

Protein identity Cavia porcellus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cavia porcellus
Tissue	Ileum
Confidence	1 — Organism
Curated By	Intermediate

Target

Cavia porcellus (CHEMBL369) ↗

Type	ORGANISM
Organism	Cavia porcellus

Publication

[Pro(3)]Dyn A(1-11)-NH(2): a dynorphin analogue with high selectivity for the kappa opioid receptor.

Schlechtingen G, Zhang L, Maycock A, DeHaven RN, Daubert JD, Cassel J, Chung NN, Schiller PW, Goodman M.
J Med Chem (2000) 43 : 2698 -2702
PubMed 10893307 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.43	9.43

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL216640	—	—	1	9.43

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL216640	—	IC50	=	0.376	nM	9.43