Assay Detail
Functional
CHEMBL843722
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Inhibition of anti-CD3 stimulated IL-2 production by Jurkat cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.87 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306380 | — | — | 1 | 5.92 |
| CHEMBL47940 | — | — | 1 | 5.82 |
| CHEMBL69129 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306380 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL47940 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL69129 | — | IC50 | < | 1.0 | nM | - |