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Assay Detail

CHEMBL844072

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Binding affinity for progesterone 6-beta-hydroxylase of hepatic microsomes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cytochrome P450 3A4 (CHEMBL340)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.
Walker KA, Kertesz DJ, Rotstein DM, Swinney DC, Berry PW, So OY, Webb AS, Watson DM, Mak AY, Burton PM.
J Med Chem (1993) 36 : 2235 -2237
PubMed 8340925 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.48 7.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL305220 1 7.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL305220 Ki = 33.0 nM 7.48