Assay Detail
Functional
CHEMBL844574
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Calcium antagonistic activity assessed against calcium-induced constriction of potassium-depolarized rat aorta.
40
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A new class of calcium antagonists. Synthesis and biological activity of 11-[(omega-aminoalkanoyl)amino]-6,6a,7,8,9,10,10a,11-octahydrodibenzo [b,e]thiepin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 40 | 7.34 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157248 | — | — | 1 | 8.16 |
| CHEMBL157859 | — | — | 1 | 8.15 |
| CHEMBL346483 | — | — | 1 | 8.05 |
| CHEMBL350910 | — | — | 1 | 7.82 |
| CHEMBL156962 | — | — | 1 | 7.82 |
| CHEMBL155550 | — | — | 1 | 7.80 |
| CHEMBL422350 | — | — | 1 | 7.77 |
| CHEMBL154726 | — | — | 1 | 7.73 |
| CHEMBL154721 | — | — | 1 | 7.72 |
| CHEMBL1788142 | — | — | 1 | 7.68 |
| CHEMBL347430 | — | — | 1 | 7.60 |
| CHEMBL435233 | — | — | 1 | 7.57 |
| CHEMBL434848 | — | — | 1 | 7.57 |
| CHEMBL346147 | — | — | 1 | 7.55 |
| CHEMBL154172 | — | — | 1 | 7.52 |
| CHEMBL158191 | — | — | 1 | 7.52 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 7.42 |
| CHEMBL155266 | — | — | 1 | 7.39 |
| CHEMBL154266 | — | — | 1 | 7.38 |
| CHEMBL421803 | — | — | 1 | 7.34 |
| CHEMBL345164 | — | — | 1 | 7.33 |
| CHEMBL346313 | — | — | 1 | 7.26 |
| CHEMBL422341 | — | — | 1 | 7.25 |
| CHEMBL345224 | — | — | 1 | 7.24 |
| CHEMBL345239 | — | — | 1 | 7.24 |
| CHEMBL156410 | — | — | 1 | 7.16 |
| CHEMBL345856 | — | — | 1 | 7.15 |
| CHEMBL154365 | — | — | 1 | 7.15 |
| CHEMBL436426 | — | — | 1 | 7.14 |
| CHEMBL154474 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157248 | — | Kd | = | 6.918 | nM | 8.16 |
| CHEMBL157859 | — | Kd | = | 7.079 | nM | 8.15 |
| CHEMBL346483 | — | Kd | = | 8.913 | nM | 8.05 |
| CHEMBL350910 | — | Kd | = | 15.14 | nM | 7.82 |
| CHEMBL156962 | — | Kd | = | 15.14 | nM | 7.82 |
| CHEMBL155550 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL422350 | — | Kd | = | 16.98 | nM | 7.77 |
| CHEMBL154726 | — | Kd | = | 18.62 | nM | 7.73 |
| CHEMBL154721 | — | Kd | = | 19.05 | nM | 7.72 |
| CHEMBL1788142 | — | Kd | = | 20.89 | nM | 7.68 |
| CHEMBL347430 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL435233 | — | Kd | = | 26.92 | nM | 7.57 |
| CHEMBL434848 | — | Kd | = | 26.92 | nM | 7.57 |
| CHEMBL346147 | — | Kd | = | 28.18 | nM | 7.55 |
| CHEMBL158191 | — | Kd | = | 30.2 | nM | 7.52 |
| CHEMBL154172 | — | Kd | = | 30.2 | nM | 7.52 |
| CHEMBL23 | DILTIAZEM | Kd | = | 38.02 | nM | 7.42 |
| CHEMBL155266 | — | Kd | = | 40.74 | nM | 7.39 |
| CHEMBL154266 | — | Kd | = | 41.69 | nM | 7.38 |
| CHEMBL421803 | — | Kd | = | 45.71 | nM | 7.34 |
| CHEMBL345164 | — | Kd | = | 46.77 | nM | 7.33 |
| CHEMBL346313 | — | Kd | = | 54.95 | nM | 7.26 |
| CHEMBL422341 | — | Kd | = | 56.23 | nM | 7.25 |
| CHEMBL345239 | — | Kd | = | 57.54 | nM | 7.24 |
| CHEMBL345224 | — | Kd | = | 57.54 | nM | 7.24 |
| CHEMBL156410 | — | Kd | = | 69.18 | nM | 7.16 |
| CHEMBL345856 | — | Kd | = | 70.79 | nM | 7.15 |
| CHEMBL154365 | — | Kd | = | 70.79 | nM | 7.15 |
| CHEMBL436426 | — | Kd | = | 72.44 | nM | 7.14 |
| CHEMBL154474 | — | Kd | = | 75.86 | nM | 7.12 |
| CHEMBL345743 | — | Kd | = | 77.62 | nM | 7.11 |
| CHEMBL157514 | — | Kd | = | 81.28 | nM | 7.09 |
| CHEMBL345403 | — | Kd | = | 97.72 | nM | 7.01 |
| CHEMBL154559 | — | Kd | = | 104.71 | nM | 6.98 |
| CHEMBL154707 | — | Kd | = | 138.04 | nM | 6.86 |
| CHEMBL436040 | — | Kd | = | 141.25 | nM | 6.85 |
| CHEMBL422863 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL155713 | — | Kd | = | 323.59 | nM | 6.49 |
| CHEMBL155713 | — | Kd | = | 331.13 | nM | 6.48 |
| CHEMBL346991 | — | Kd | = | 416.87 | nM | 6.38 |