Assay Detail
Functional
CHEMBL844871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against progesterone receptor (PR) in an assay using PRE-luciferase plasmid co-transfected CV-1 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: a novel class of potent, selective, and orally active nonsteroidal progesterone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.54 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136376 | — | — | 1 | 8.59 |
| CHEMBL138005 | — | — | 1 | 8.42 |
| CHEMBL139749 | — | — | 1 | 8.17 |
| CHEMBL136806 | — | — | 1 | 8.03 |
| CHEMBL303209 | — | — | 1 | 8.00 |
| CHEMBL136322 | — | — | 1 | 7.80 |
| CHEMBL343306 | — | — | 1 | 7.43 |
| CHEMBL136166 | — | — | 1 | 7.42 |
| CHEMBL138059 | — | — | 1 | 7.40 |
| CHEMBL136721 | — | — | 1 | 7.26 |
| CHEMBL139406 | — | — | 1 | 7.00 |
| CHEMBL343083 | — | — | 1 | 6.30 |
| CHEMBL342199 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136376 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL138005 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL139749 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL136806 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL303209 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL136322 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL343306 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL136166 | — | IC50 | = | 38.3 | nM | 7.42 |
| CHEMBL138059 | — | IC50 | = | 40.2 | nM | 7.40 |
| CHEMBL136721 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL139406 | — | IC50 | = | 98.8 | nM | 7.00 |
| CHEMBL343083 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL342199 | — | IC50 | = | 642.0 | nM | 6.19 |