Compound Detail
CHEMBL136376
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Basic Information
| ChEMBL ID | CHEMBL136376 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QFJFPUFDMQGULL-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
305.7
MW (Da)
4.94
ALogP
2
HBA
1
HBD
38.3
PSA (Ų)
0.81
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.3
IC50 1 meas. best 8.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | IC50 | 8.59 | 8.59 | 2.6 | 1 |
| Progesterone receptor CHEMBL208 | EC50 | 6.3 | 6.3 | 500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | IC50 | = | 2.6 | nM | 8.59 | Antagonist activity against progesterone receptor (PR) in an assay using PRE-luc... | 12238914 |
| Progesterone receptor | EC50 | = | 500.0 | nM | 6.3 | Agonist activity against progesterone receptor (PR) in an alkaline phosphatase a... | 12238914 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12238914 | 10.1021/jm025555e | Progesterone receptor | 4 |
| 12238914 | 10.1021/jm025555e | Estrogen receptor | 1 |
Data from ChEMBL 36 via Core Engine