Assay Detail
Functional
CHEMBL845400
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Calcium sensitizing activity
8
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Stereoselectivity of the positive inotropic effects of newer diazinone-cardiotonics
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.89 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314612 | — | — | 2 | 5.77 |
| CHEMBL24646 | PIMOBENDAN | 2.0 | 2 | 4.00 |
| CHEMBL85074 | MERIBENDAN | 2.0 | 2 | - |
| CHEMBL313136 | SIMENDAN | 2.0 | 1 | - |
| CHEMBL2051955 | LEVOSIMENDAN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314612 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL24646 | PIMOBENDAN | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL85074 | MERIBENDAN | EC50 | = | 190000.0 | nM | - |
| CHEMBL313136 | SIMENDAN | EC50 | >> | 100000.0 | nM | - |
| CHEMBL314612 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL85074 | MERIBENDAN | EC50 | = | 470000.0 | nM | - |
| CHEMBL2051955 | LEVOSIMENDAN | EC50 | >> | 100000.0 | nM | - |
| CHEMBL24646 | PIMOBENDAN | EC50 | = | 152000.0 | nM | - |