Assay Detail
Binding
CHEMBL846478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for in vitro inhibition of the displacement of (+)-[3H]pentazocine from sigma opioid receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 4.78 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312471 | — | — | 1 | 5.32 |
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312471 | — | Ki | = | 4815.0 | nM | 5.32 |
| CHEMBL284237 | DIZOCILPINE | Ki | = | 59167.0 | nM | 4.23 |