Assay Detail
Binding
CHEMBL846630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against sigma receptor from guinea pig brain, using [3H](+)-pentazocine as radioligand.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.60 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70540 | — | — | 1 | 9.41 |
| CHEMBL312766 | — | — | 1 | 9.28 |
| CHEMBL420557 | — | — | 1 | 8.92 |
| CHEMBL71049 | — | — | 1 | 8.91 |
| CHEMBL70861 | — | — | 1 | 8.29 |
| CHEMBL324392 | — | — | 1 | 7.98 |
| CHEMBL2368719 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70540 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL312766 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL420557 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL71049 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL70861 | — | Ki | = | 5.07 | nM | 8.29 |
| CHEMBL324392 | — | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL2368719 | — | Ki | = | 38.9 | nM | 7.41 |