Assay Detail
Functional
CHEMBL847142
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Compound was tested for Antagonistic activity against denuded rat aorta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.46 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333174 | — | — | 1 | 9.50 |
| CHEMBL120903 | — | — | 1 | 9.20 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.62 |
| CHEMBL121744 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333174 | — | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL120903 | — | Kd | = | 0.631 | nM | 9.20 |
| CHEMBL42 | CLOZAPINE | Kd | = | 2.399 | nM | 8.62 |
| CHEMBL121744 | — | Kd | = | 316.23 | nM | 6.50 |