Assay Detail
Binding
CHEMBL847532
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Inhibition of [3H]paroxetine binding to serotonin transporter (SERT) of rat cortical membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.36 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23034 | — | — | 1 | 9.40 |
| CHEMBL429065 | — | — | 1 | 9.01 |
| CHEMBL278809 | — | — | 1 | 8.90 |
| CHEMBL23033 | — | — | 1 | 8.83 |
| CHEMBL22183 | — | — | 1 | 8.78 |
| CHEMBL278165 | — | — | 1 | 8.72 |
| CHEMBL22216 | — | — | 1 | 8.65 |
| CHEMBL284002 | — | — | 1 | 8.60 |
| CHEMBL22259 | — | — | 1 | 8.56 |
| CHEMBL22743 | — | — | 1 | 8.10 |
| CHEMBL22643 | — | — | 1 | 7.71 |
| CHEMBL277045 | — | — | 1 | 7.27 |
| CHEMBL22436 | — | — | 1 | 6.16 |
| CHEMBL441022 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23034 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL429065 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL278809 | — | Ki | = | 1.25 | nM | 8.90 |
| CHEMBL23033 | — | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL22183 | — | Ki | = | 1.65 | nM | 8.78 |
| CHEMBL278165 | — | Ki | = | 1.92 | nM | 8.72 |
| CHEMBL22216 | — | Ki | = | 2.23 | nM | 8.65 |
| CHEMBL284002 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL22259 | — | Ki | = | 2.75 | nM | 8.56 |
| CHEMBL22743 | — | Ki | = | 7.96 | nM | 8.10 |
| CHEMBL22643 | — | Ki | = | 19.3 | nM | 7.71 |
| CHEMBL277045 | — | Ki | = | 53.3 | nM | 7.27 |
| CHEMBL22436 | — | Ki | = | 695.0 | nM | 6.16 |
| CHEMBL441022 | — | Ki | > | 1000.0 | nM | - |