Assay Detail
Binding
CHEMBL847756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of sigma receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
From hit to lead. Analyzing structure-profile relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.13 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114280 | — | — | 1 | 6.48 |
| CHEMBL113956 | — | — | 1 | 6.32 |
| CHEMBL115652 | — | — | 1 | 6.24 |
| CHEMBL326263 | — | — | 1 | 6.15 |
| CHEMBL115280 | — | — | 1 | 5.90 |
| CHEMBL115249 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114280 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL113956 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL115652 | — | IC50 | = | 581.0 | nM | 6.24 |
| CHEMBL326263 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL115280 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL115249 | — | IC50 | = | 2170.0 | nM | 5.66 |