Assay Detail
Binding
CHEMBL847758
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In vitro for binding affinity against sigma receptor using [3H](+)-3-PPP as radioligand
46
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines and 3-phenylpiperidines: effects on central dopamine and sigma receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 6.87 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69169 | — | — | 1 | 8.30 |
| CHEMBL68989 | — | — | 1 | 8.30 |
| CHEMBL68855 | — | — | 1 | 8.10 |
| CHEMBL45778 | — | — | 1 | 8.05 |
| CHEMBL68432 | — | — | 2 | 8.00 |
| CHEMBL67584 | — | — | 2 | 8.00 |
| CHEMBL69500 | — | — | 1 | 7.96 |
| CHEMBL70186 | — | — | 1 | 7.85 |
| CHEMBL66208 | — | — | 1 | 7.80 |
| CHEMBL67329 | — | — | 1 | 7.77 |
| CHEMBL67583 | — | — | 4 | 7.72 |
| CHEMBL305000 | — | — | 1 | 7.64 |
| CHEMBL67440 | — | — | 1 | 7.57 |
| CHEMBL48219 | — | — | 1 | 7.51 |
| CHEMBL7393 | — | — | 1 | 7.50 |
| CHEMBL2114053 | — | — | 2 | 7.32 |
| CHEMBL68916 | — | — | 1 | 7.31 |
| CHEMBL70929 | — | — | 1 | 7.19 |
| CHEMBL305793 | — | — | 1 | 7.16 |
| CHEMBL47750 | — | — | 1 | 6.96 |
| CHEMBL7549 | PRECLAMOL | 2.0 | 1 | 6.78 |
| CHEMBL306162 | — | — | 1 | 6.71 |
| CHEMBL424223 | — | — | 1 | 6.68 |
| CHEMBL56617 | — | — | 1 | 6.66 |
| CHEMBL68952 | — | — | 1 | 6.63 |
| CHEMBL432125 | — | — | 1 | 6.61 |
| CHEMBL305438 | — | — | 1 | 6.56 |
| CHEMBL49617 | — | — | 1 | 6.43 |
| CHEMBL450863 | — | — | 1 | 6.36 |
| CHEMBL56618 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69169 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL68989 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL68855 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL45778 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL68432 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL67584 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL69500 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL70186 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL66208 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL67329 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL67583 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL67583 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL305000 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL67440 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL48219 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL7393 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL68432 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL67584 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2114053 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL68916 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL70929 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL67583 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL305793 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL47750 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL7549 | PRECLAMOL | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL306162 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL424223 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL56617 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL68952 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL432125 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL305438 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL49617 | — | IC50 | = | 373.0 | nM | 6.43 |
| CHEMBL2114053 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL450863 | — | IC50 | = | 438.0 | nM | 6.36 |
| CHEMBL67583 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL56618 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL49597 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL8626 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL56630 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL412642 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL2114055 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL56519 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL8268 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL56630 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL302244 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL8033 | — | IC50 | = | 15600.0 | nM | 4.81 |