Assay Detail
Binding
CHEMBL848642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The binding affinity was measured on sigma receptor using [3H]- (+)-3-PPP as radioligand.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.32 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103778 | CILANSETRON | 2.0 | 1 | 6.47 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103778 | CILANSETRON | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL46 | ONDANSETRON | Ki | = | 680.0 | nM | 6.17 |