Assay Detail
ADMET
CHEMBL853201
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Inhibition of CYP3A4
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid as a highly potent and selective retinoic acid metabolic blocking agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.64 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207486 | — | — | 1 | 6.40 |
| CHEMBL207411 | — | — | 1 | 6.35 |
| CHEMBL208155 | — | — | 1 | 6.24 |
| CHEMBL207304 | — | — | 1 | 6.10 |
| CHEMBL205862 | — | — | 1 | 6.00 |
| CHEMBL210780 | — | — | 1 | 5.77 |
| CHEMBL382574 | — | — | 1 | 5.68 |
| CHEMBL208158 | — | — | 1 | 5.67 |
| CHEMBL207942 | — | — | 1 | 5.64 |
| CHEMBL205280 | — | — | 1 | 5.64 |
| CHEMBL208443 | — | — | 1 | 5.48 |
| CHEMBL377286 | — | — | 1 | 5.28 |
| CHEMBL208154 | — | — | 1 | 5.20 |
| CHEMBL207345 | — | — | 1 | 5.16 |
| CHEMBL206884 | — | — | 1 | 5.12 |
| CHEMBL207638 | — | — | 1 | 5.10 |
| CHEMBL377177 | — | — | 1 | 5.09 |
| CHEMBL210569 | — | — | 1 | - |
| CHEMBL204684 | — | — | 1 | - |
| CHEMBL378132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207486 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL207411 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL208155 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL207304 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL205862 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL210780 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL382574 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL208158 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL207942 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL205280 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL208443 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL377286 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL208154 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL207345 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL206884 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL207638 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL377177 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL210569 | — | IC50 | - | — | - | |
| CHEMBL204684 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL378132 | — | IC50 | > | 20000.0 | nM | - |