Assay Detail
ADMET
CHEMBL853213
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Plasma concentration for reduction of DEA-extractable brain beta amyloid in orally dosed APP-YAC mouse after 4 hrs relative to control
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Tissue | Brain/Plasma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.51 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209888 | — | — | 1 | 6.98 |
| CHEMBL377691 | — | — | 1 | 6.42 |
| CHEMBL377264 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209888 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL377691 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL377264 | — | EC50 | = | 761.0 | nM | 6.12 |