Assay Detail
ADMET
CHEMBL853214
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Brain concentration for reduction of DEA-extractable brain beta amyloid in orally dosed APP-YAC mouse after 4 hrs relative to control
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.08 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209888 | — | — | 1 | 7.70 |
| CHEMBL377691 | — | — | 1 | 7.06 |
| CHEMBL377264 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209888 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL377691 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL377264 | — | EC50 | = | 327.0 | nM | 6.49 |