Assay Detail
Functional
CHEMBL853561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse fibroblast L(tk-) cells transfected with human NMDA using LDH assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.74 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201440 | — | — | 1 | 5.28 |
| CHEMBL201795 | — | — | 1 | 5.10 |
| CHEMBL202412 | — | — | 1 | 4.81 |
| CHEMBL263962 | — | — | 1 | 4.81 |
| CHEMBL199848 | — | — | 1 | 4.80 |
| CHEMBL370772 | — | — | 1 | 4.80 |
| CHEMBL201059 | — | — | 1 | 4.25 |
| CHEMBL383662 | — | — | 1 | 4.05 |
| CHEMBL202705 | — | — | 1 | - |
| CHEMBL382307 | — | — | 1 | - |
| CHEMBL379891 | — | — | 1 | - |
| CHEMBL203300 | — | — | 1 | - |
| CHEMBL201235 | — | — | 1 | - |
| CHEMBL203209 | — | — | 1 | - |
| CHEMBL199667 | — | — | 1 | - |
| CHEMBL382523 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201440 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL201795 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL202412 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL263962 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL199848 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL370772 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL201059 | — | IC50 | = | 55800.0 | nM | 4.25 |
| CHEMBL383662 | — | IC50 | = | 89200.0 | nM | 4.05 |
| CHEMBL202705 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL382307 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL379891 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL203300 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL201235 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL203209 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL199667 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL382523 | — | IC50 | > | 250000.0 | nM | - |